Endocrine Abstracts

Background and aims: Less than total thyroidectomy (lobectomy, partial or subtotal thyroidectomy) is used mainly to treat thyroid nodules, and/or hyperthyroidism. The aim of the study was to investigate the long term effects of less extensive surgical procedures. such as re-appearance of nodules and the need of thyroxin supplementation, or re-operation.Material and methods: Retrospective study in a tertiary Academic medical center. The study population c...

Although classical and non-classical signaling of testosterone (T) has been observed in the testis, the enigma of the non-classical pathway is not fully resolved. While some researchers favor the androgen receptor (AR), others propose a membrane-bound receptor for non-classical T signaling. Although silencing of the AR in Sertoli cells (SC) resulted in infertility and suggested no involvement of the non-classical pathway, recent experiments using an inhibitor of the non-classi...

Introduction: Hormonal replacement therapy (HRT) increases bone mineral density (BMD). Controversy exists regarding residual effect after withdrawal. We aimed to explore the effect of HRT and HRT withdrawal on: i) BMD and bone microarchitecture assessed by trabecular bone score (TBS); ii) fat (FMI), lean (LMI) and appendicular lean (ALMI) mass indexes.Methods: The OsteoLaus Cohort assessed 1500 women (50–80 years) for BMD, TBS, total energy expendit...

Introduction: Extended Forsteo® Observational Study (ExFOS), a multinational, non-interventional, prospective, observational study, designed to evaluate fractures, back pain (BP), adherence and health-related quality of life (QoL) in teriparatide (TPTD) treated patients, based on the extension of treatment duration (24 months) and the addition of new indications (glucocorticoid-induced and male osteoporosis) was compared with EFOS.Methods...

Introduction: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue (>50%). It accounts for ~5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most struma ovarii are benign with only 5–10% being malignant. Malignant SO causing thyrotoxicosis is very uncommon.Case presentation: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years ago. The thyroid gl...

Introduction: A significant body of literature supports that 25(OH)vitD deficiency is associated with insulin resistance. We studied the prevalence of 25(OH)vitD deficiency across the spectrum of glucose metabolism.Design: The study participants (441 total, 362 females (82.1%) and 79 males (17.9%)) had a mean age (±S.D.) of 64.59 (±9.44) years, range: 32–92 years. The study population was divided into two groups: Individuals...

Introduction: Virilizing tumors are rare, but frequent cause of virilization in postmenopausal women.Case report: A 62-year-old postmenopausal woman presented with a rapid onset of hirsutism with increased terminal hair growth, particular on chin and abdomen, frontal male pattern balding in the last 5 months. Physical examination revealed a low-pitched, deepened voice and clitoromegaly. The Ferriman–Gallwey score was 18. Laboratory evaluation: Testo...

Introduction: Bisphenol A (BPA) is a chemical compound found in a variety of everyday products. Exposure to BPA impacts negatively ovarian response, number of fertilized oocytes and implantation in women undergoing in vitro fertilization (IVF). The aim of the study was to determine BPA levels in women with polycystic ovary syndrome (PCOS) in comparison to women with tubal factor (TF) infertility who underwent IVF as well as to investigate their effect in critical endp...

Introduction: Commonly used pre-operative methods (ultrasonography and sestamibi scan) to localize the culprit parathyroid gland(s) in patients with primary hyperparathyroidism (PHPT), frequently yield false positive or false negative results. Parathyroid hormone (PTH) washout after fine-needle aspiration (FNA) may allow for a targeted surgical approach. The aim of this study was to test the diagnostic value of preoperative PTH washout after FNA in PHPT patients.<p class="...

Introduction: Vitamin D deficiency has been reported to be widely found within the population. Vitamin D deficiency was also found to be prevalent in patients with autoimmune inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. Vitamin D deficiency was reported in almost all patients with acute myocardial infarction in a US multicenter study. Low concentrations of 25-hydroxyvitamin D (25(OH)D) are reported to be an independent risk factor for ca...